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Recombinant Human DENND1A Protein, GST-tagged

Cat.No. : DENND1A-2532H
Product Overview : Human DENND1A full-length ORF ( NP_079096.2, 1 a.a. - 559 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 89.8 kDa
AA Sequence : MGSRIKQNPETTFEVYVEVAYPRTG GTLSDPEVQRQFPEDYSDQEVLQTL TKFCFPFYVDSLTVSQVGQNFTFVL TDIDSKQRFGFCRLSSGAKSCFCIL SYLPWFEVFYKLLNILADYTTKRQE NQWNELLETLHKLPIPDPGVSVHLS VHSYFTVPDTRELPSIPENRNLTEY FVAVDVNNMLHLYASMLYERRILII CSKLSTLTACIHGSAAMLYPMYWQH VYIPVLPPHLLDYCCAPMPYLIGIH LSLMEKVRNMALDDVVILNVDTNTL ETPFDDLQSLPNDVISSLKNRLKKV STTTGDGVARAFLKAQAAFFGSYRN ALKIEPEEPITFCEEAFVSHYRSGA MRQFLQNATQLQLFKQFIDGRLDLL NSGEGFSDVFEEEINMGEYAGSDKL YHQWLSTVRKGSGAILNTVKTKANP AMKTVYKFAKDHAKMGIKEVKNRLK QKDIAENGCAPTPEEQLPKTAPSPL VEAKDPKLREDRRPITVHFGQVRPP RPHVVKRPKSNIAVEGRRTSVPSPE QNTIATPATLHILQKSITHFAAKFP TRGWTSSSH
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DENND1A DENN/MADD domain containing 1A [ Homo sapiens ]
Official Symbol : DENND1A
Synonyms : FAM31A; KIAA1608; RP11-230L22.3
Gene ID : 57706
mRNA Refseq : NM_024820.2
Protein Refseq : NP_079096.2
MIM : 613633
UniProt ID : Q8TEH3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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