Recombinant Human DENND1C Protein, GST-tagged

• Cat.No.: DENND1C-2534H
• Product Overview: Human DENND1C full-length ORF ( NP_079174.2, 1 a.a. - 801 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene functions as a guanine nucleotide exchange factor for the early endosomal small GTPase RAB35, which regulates endosomal membrane trafficking and is involved in actin polymerization. The encoded protein activates RAB35 by promoting the exchange of RAB35-bound GDP for GTP. This gene may play a role in linking RAB35 activation with the clathrin machinery. [provided by RefSeq, May 2017]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 113.5 kDa
• AA Sequence: MESRAEGGSPAVFDWFFEAACPASL QEDPPILRQFPPDFRDQEAMQMVPK FCFPFDVEREPPSPAVQHFTFALTD LAGNRRFGFCRLRAGTQSCLCILSH LPWFEVFYKLLNTVGDLLAQDQVTE AEELLQNLFQQSLSGPQASVGLELG SGVTVSSGQGIPPPTRGNSKPLSCF VAPDSGRLPSIPENRNLTELVVAVT DENIVGLFAALLAERRVLLTASKLS TLTSCVHASCALLYPMRWEHVLIPT LPPHLLDYCCAPMPYLIGVHASLAE RVREKALEDVVVLNVDANTLETTFN DVQALPPDVVSLLRLRLRKVALAPG EGVSRLFLKAQALLFGGYRDALVCS PGQPVTFSEEVFLAQKPGAPLQAFH RRAVHLQLFKQFIEARLEKLNKGEG FSDQFEQEITGCGASSGALRSYQLW ADNLKKGGGALLHSVKAKTQPAVKN MYRSAKSGLKGVQSLLMYKDGDSVL QRGGSLRAPALPSRSDRLQQRLPIT QHFGKNRPLRPSRRRQLEEGTSEPP GAGTPPLSPEDEGCPWAEEALDSSF LGSGEELDLLSEILDSLSMGAKSAG SLRPSQSLDCCHRGDLDSCFSLPNI PRWQPDDKKLPEPEPQPLSLPSLQN ASSLDATSSSKDSRSQLIPSESDQE VTSPSQSSTASADPSIWGDPKPSPL TEPLILHLTPSHKAAEDSTAQENPT PWLSTAPTEPSPPESPQILAPTKPN FDIAWTSQPLDPSSDPSSLEDPRAR PPKALLAERAHLQPREEPGALNSPA TPTSNCQKSQPSSRPRVADLKKCFE G
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DENND1C DENN/MADD domain containing 1C [ Homo sapiens ]
• Official Symbol: DENND1C
• Synonyms: FAM31C
• Gene ID: 79958
• mRNA Refseq: NM_024898.2
• Protein Refseq: NP_079174.2
• MIM: 613634
• UniProt ID: Q8IV53