Recombinant Human DGCR2 Protein, GST-tagged

• Cat.No.: DGCR2-2564H
• Product Overview: Human DGCR2 full-length ORF ( NP_005128.1, 1 a.a. - 550 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 87.2 kDa
• AA Sequence: MVPKADSGAFLLLFLLVLTVTEPLR PELRCNPGQFACRSGTIQCIPLPWQ CDGWATCEDESDEANCPEVTGEVRP HHGKEAVDPRQGRARGGDPSHFHAV NVAQPVRFSSFLGKCPTGWHHYEGT ASCYRVYLSGENYWDAAQTCQRLNG SLATFSTDQELRFVLAQEWDQPERS FGWKDQRKLWVGYQYVITGRNRSLE GRWEVAFKGSSEVFLPPDPIFASAM SENDNVFCAQLQCFHFPTLRHHDLH SWHAESCYEKSSFLCKRSQTCVDIK DNVVDEGFYFTPKGDDPCLSCTCHG GEPEMCVAALCERPQGCQQYRKDPK ECCKFMCLDPDGNSLFDSMASGMRL VVSCISSFLILSLLLFMVHRLRQRR RERIESLIGANLHHFNLGRRIPGFD YGPDGFGTGLTPLHLSDDGEGGTFH FHDPPPPYTAYKYPDIGQPDDPPPP YEASIHPDSVFYDPADDDAFEPVEV SLPAPGDGGSEGALLRRLEQPLPTA GASLADLEDSADSSSALLVPPDPAQ SGSTPAAEALPGGGRHSRSSLNTVV
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DGCR2 DiGeorge syndrome critical region gene 2 [ Homo sapiens ]
• Official Symbol: DGCR2
• Synonyms: DGS C; DGS2; DiGeorge syndrome critical region gene 2; IDD; integral membrane protein DGCR2; LAN; SEZ 12; DiGeorge syndrome critical region protein 2; integral membrane protein deleted in DiGeorge syndrome
• Gene ID: 9993
• mRNA Refseq: NM_005137.2
• Protein Refseq: NP_005128.1
• MIM: 600594
• UniProt ID: P98153