"DHCR24" Related Products


Recombinant Human DHCR24 protein, MYC/DDK-tagged

Cat.No.: DHCR24-105H
Product Overview: Recombinant Human DHCR24 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Source: HEK293
Species: Human
Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass: 57.6 kDa
Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Concentration: >50 ug/mL as determined by microplate BCA method
Gene Name: DHCR24 24-dehydrocholesterol reductase [ Homo sapiens ]
Official Symbol: DHCR24
Synonyms: DHCR24; 24-dehydrocholesterol reductase; delta(24)-sterol reductase; KIAA0018; seladin 1; diminuto/dwarf1 homolog; selective AD indicator 1; desmosterol-to-cholesterol enzyme; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol delta-24-reductase; DCE; SELADIN1; Nbla03646; seladin-1;
Gene ID: 1718
mRNA Refseq: NM_014762
Protein Refseq: NP_055577
MIM: 606418
UniProt ID: Q15392

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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