Recombinant Human DIMT1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DIMT1-1213H
• Product Overview: DIMT1L MS Standard C13 and N15-labeled recombinant protein (NP_055288) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a methyltransferase that is responsible for dimethylation of adjacent adenosines near the 18S rRNA decoding site. The encoded protein is essential for ribosome biogenesis, although its catalytic activity is not involved in the process. The yeast ortholog of this protein functions in the cytoplasm while this protein functions in the nucleus.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 35.2 kDa
• AA Sequence: MPKVKSGAIGRRRGRQEQRRELKSA GGLMFNTGIGQHILKNPLIINSIID KAALRPTDVVLEVGPGTGNMTVKLL EKAKKVVACELDPRLVAELHKRVQG TPVASKLQVLVGDVLKTDLPFFDTC VANLPYQISSPFVFKLLLHRPFFRC AILMFQREFALRLVAKPGDKLYCRL SINTQLLARVDHLMKVGKNNFRPPP KVESSVVRIEPKNPPPPINFQEWDG LVRITFVRKNKTLSAAFKSSAVQQL LEKNYRIHCSVHNIIIPEDFSIADK IQQILTSTGFSDKRARSMDIDDFIR LLHGFNAEGIHFSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DIMT1 DIMT1 rRNA methyltransferase and ribosome maturation factor [ Homo sapiens (human) ]
• Official Symbol: DIMT1
• Synonyms: DIMT1; DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); DIM1 dimethyladenosine transferase 1 like (S. cerevisiae), DIMT1L; probable dimethyladenosine transferase; HSA9761; 18S rRNA dimethylase; dimethyladenosine transferase; probable 18S rRNA dimethylase; S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase; 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; probable S-adenosylmethionine-6-N,N-adenosyl(rRNA) dimethyltransferase; probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase; DIM1; DIMT1L; HUSSY5
• Gene ID: 27292
• mRNA Refseq: NM_014473
• Protein Refseq: NP_055288
• MIM: 612499
• UniProt ID: Q9UNQ2