Recombinant Human DMD Protein (Lys3200-Thr3684), N-His tagged

• Cat.No.: DMD-01H
• Product Overview: Purified recombinant protein of Human dystrophin (DMD), transcript variant Dp427m, Lys3200-Thr3684, with N-terminal His tag, expressed in E.coli.

Specification

• Description: This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene.
• Source: E. coli
• Species: Human
• Tag: N-His
• Molecular Mass: 55.0 kDa
• Protein Length: Lys3200-Thr3684
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea

Gene Information

• Gene Name: DMD dystrophin [ Homo sapiens (human) ]
• Official Symbol: DMD
• Synonyms: DMD; dystrophin; dystrophin (muscular dystrophy, Duchenne and Becker types), includes DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272; BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; muscular dystrophy; Duchenne and Becker types; CMD3B
• Gene ID: 1756
• mRNA Refseq: NM_004006
• Protein Refseq: NP_003997
• MIM: 300377
• UniProt ID: P11532