| Description : |
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
70.6 kDa |
| AA Sequence : |
MREQLKGHETQTTCWDHPKMTELYQ SLADLNNVRFSAYRTAMKLRRLQKA LCLDLLSLSAACDALDQHNLKQNDQ PMDILQIINCLTTIYDRLEQEHNNL VNVPLCVDMCLNWLLNVYDTGRTGR IRVLSFKTGIISLCKAHLEDKYRYL FKQVASSTGFCDQRRLGLLLHDSIQ IPRQLGEVASFGGSNIEPSVRSCFQ FANNKPEIEAALFLDWMRLEPQSMV WLPVLHRVAAAETAKHQAKCNICKE CPIIGFRYRSLKHFNYDICQSCFFS GRVAKGHKMHYPMVEYCTPTTSGED VRDFAKVLKNKFRTKRYFAKHPRMG YLPVQTVLEGDNMETPASSPQLSHD DTHSRIEHYASRLAEMENSNGSYLN DSISPNESIDDEHLLIQHYCQSLNQ DSPLSQPRSPAQILISLESEERGEL ERILADLEEENRNLQAEYDRLKQQH EHKGLSPLPSPPEMMPTSPQSPRDA ELIAEAKLLRQHKGRLEARMQILED HNKQLESQLHRLRQLLEQPQAEAKV NGTTVSSPSTSLQRSDSSQPMLLRV VGSQTSDSMGEEDLLSPPQDTSTGL EEVMEQLNNSFPSSRGHNVGSLFHM ADDLGRAMESLVSVMTDEEGAETRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
