Recombinant Human DOCK8 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | DOCK8-3734H |
| Product Overview : | DOCK8 MS Standard C13 and N15-labeled recombinant protein (NP_982272) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 238.3 kDa |
| AA Sequence : | MTHLNSLDVQ LAQELGDFTD DDLDVVFTPK ECRTLQPSLP EEGVELDPHV RDCVQTYIRE WLIVNRKNQG SPEICGFKKT GSRKDFHKTL PKQTFESETL ECSEPAAQAG PRHLNVLCDV SGKGPVTACD FDLRSLQPDK RLENLLQQVS AEDFEKQNEE ARRTNRQAEL FALYPSVDEE DAVEIRPVPE CPKEHLGNRI LVKLLTLKFE IEIEPLFASI ALYDVKERKK ISENFHCDLN SDQFKGFLRA HTPSVAASSQ ARSAVFSVTY PSSDIYLVVK IEKVLQQGEI GDCAEPYTVI KESDGGKSKE KIEKLKLQAE SFCQRLGKYR MPFAWAPISL SSFFSVSTLE REVTDVDSVV GRSSVGERRT LAQSRRLSER ALSLEENGVG SNFKTSTLSV SIFFKQEGDR LSDEDLFKFL ADYKRSSSLQ RRVKSIPGLL RLEISTAPEI INCCLTPEML PVKPFPENRT RPHKEILEFP TREVYVPHTV YRNLLYVYPQ RLNFVNKLAS ARNITIKIQF MCGEDASNAM PVIFGKSSGP EFLQEVYTAV TYHNKSPDFY EEVKIKLPAK LTVNHHLLFT FYHISCQQKQ GASVETLLGY SWLPILLNER LQTGSYCLPV ALEKLPPNYS MHSAEKVPLQ NPPIKWAEGH KGVFNIEVQA VSSVHTQDNH LEKFFTLCHS LESQVTFPIR VLDQKISEMA LEHELKLSII CLNSSRLEPL VLFLHLVLDK LFQLSVQPMV IAGQTANFSQ FAFESVVAIA NSLHNSKDLS KDQHGRNCLL ASYVHYVFRL PEVQRDVPKS DAPTALLDPR SYHTYGRTSA AAVSSKLLQA RVMSSSNPDL AGTHSAADEE VKNIMSSKIA DRNCSRMSYY CSGSSDAPSS PAAPRPASKK HFHEELALQM VVSTGMVRET VFKYAWFFFE LLVKSMAQHV HNMDKRDSFR RTRFSDRFMD DITTIVNVVT SEIAALLVKP QKENEQAEKM NISLAFFLYD LLSLMDRGFV FNLIRHYCSQ LSAKLSNLPT LISMRLEFLR ILCSHEHYLN LNLFFMNADT APTSPCPSIS SQNSSSCSSF QDQKIASMFD LTSEYRQQHF LTGLLFTELA AALDAEGEGI SKVQRKAVSA IHSLLSSHDL DPRCVKPEVK VKIAALYLPL VGIILDALPQ LCDFTVADTR RYRTSGSDEE QEGAGAINQN VALAIAGNNF NLKTSGIVLS SLPYKQYNML NADTTRNLMI CFLWIMKNAD QSLIRKWIAD LPSTQLNRIL DLLFICVLCF EYKGKQSSDK VSTQVLQKSR DVKARLEEAL LRGEGARGEM MRRRAPGNDR FPGLNENLRW KKEQTHWRQA NEKLDKTKAE LDQEALISGN LATEAHLIIL DMQENIIQAS SALDCKDSLL GGVLRVLVNS LNCDQSTTYL THCFATLRAL IAKFGDLLFE EEVEQCFDLC HQVLHHCSSS MDVTRSQACA TLYLLMRFSF GATSNFARVK MQVTMSLASL VGRAPDFNEE HLRRSLRTIL AYSEEDTAMQ MTPFPTQVEE LLCNLNSILY DTVKMREFQE DPEMLMDLMY RIAKSYQASP DLRLTWLQNM AEKHTKKKCY TEAAMCLVHA AALVAEYLSM LEDHSYLPVG SVSFQNISSN VLEESVVSED TLSPDEDGVC AGQYFTESGL VGLLEQAAEL FSTGGLYETV NEVYKLVIPI LEAHREFRKL TLTHSKLQRA FDSIVNKDHK RMFGTYFRVG FFGSKFGDLD EQEFVYKEPA ITKLPEISHR LEAFYGQCFG AEFVEVIKDS TPVDKTKLDP NKAYIQITFV EPYFDEYEMK DRVTYFEKNF NLRRFMYTTP FTLEGRPRGE LHEQYRRNTV LTTMHAFPFI KTRISVIQKE EFVLTPIEVA IEDMKKKTLQ LAVAINQEPP DAKMLQMVLQ GSVGATVNQG PLEVAQVFLA EIPADPKLYR HHNKLRLCFK EFIMRCGEAV EKNKRLITAD QREYQQELKK NYNKLKENLR PMIERKIPEL YKPIFRVESQ KRDSFHRSSF RKCETQLSQG STRTRPLEQK LISEEDLAAN DILDYKDDDD KV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | DOCK8 dedicator of cytokinesis 8 [ Homo sapiens (human) ] |
| Official Symbol : | DOCK8 |
| Synonyms : | DOCK8; dedicator of cytokinesis 8; MRD2; ZIR8; HEL-205; dedicator of cytokinesis protein 8; 1200017A24Rik; epididymis luminal protein 205 |
| Gene ID : | 81704 |
| mRNA Refseq : | NM_203447 |
| Protein Refseq : | NP_982272 |
| MIM : | 611432 |
| UniProt ID : | Q8NF50 |
◆ Recombinant Protein
| DOCK8-2418M | Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged | +Inquiry |
| Dock8-2628M | Recombinant Mouse Dock8 Protein, Myc/DDK-tagged | +Inquiry |
| DOCK8-2255H | Recombinant Human DOCK8 Protein (560-729 aa), His-tagged | +Inquiry |
| DOCK8-2251M | Recombinant Mouse DOCK8 Protein (561-730 aa), His-tagged | +Inquiry |
| DOCK8-12H | Recombinant Human DOCK8 protein, MYC/DDK-tagged | +Inquiry |
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