| Description : |
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
90.9 kDa |
| AA Sequence : |
MNQTASVSHHIKCQPSKTIKELGSN SPPQRNWKGIAIALLVILVVCSLIT MSVILLTPDELTNSSETRLSLEDLF RKDFVLHDPEARWINDTDVVYKSEN GHVIKLNIETNATTLLLENTTFVTF KASRHSVSPDLKYVLLAYDVKQIFH YSYTASYVIYNIHTREVWELNPPEV EDSVLQYAAWGVQGQQLIYIFENNI YYQPDIKSSSLRLTSSGKEEIIFNG IADWLYEEELLHSHIAHWWSPDGER LAFLMINDSLVPTMVIPRFTGALYP KGKQYPYPKAGQMNPTIKLYVVNLY GPTHTLELMPPDSFKSREYYITMVK WVSNTKTVVRWLNRAQNISILTVCE TTTGACSKKYEMTSDTWLSQQNEEP VFSRDGSKFFMTVPVKQGGRGEFHH IAMFLIQSKSEQITVRHLTSGNWEV IKILAYDETTQKIYFLSTESSPRGR QLYSASTEGLLNRQCISCNFMKEQC TYFDASFSPMNQHFLLFCEGPRVPV VSLHSTDNPAKYFILESNSMLKEAI LKKKIGKPEIKILHIDDYELPLQLS LPKDFMDRNQYALLLIMDEEPGGQL VTDKFHIDWDSVLIDMDNVIVARFD GRGSGFQGLKILQEIHRRLGSVEVK DQITAVKFLLKLPYIDSKRLSIFGK GYGGYIASMILKSDEKLFKCGSVVA PITDLKLYASAFSERYLGMPSKEES TYQAASVLHNVHGLKEENILIIHGT ADTKVHFQHSAELIKHLIKAGVNYT MQVYPDEGHNVSEKSKYHLYSTILK FFSDCLKEEISVLPQEPEEDETRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
