Recombinant Human DRAXIN Protein (26-349 aa), His-SUMO-tagged

• Cat.No.: DRAXIN-1977H
• Product Overview: Recombinant Human DRAXIN Protein (26-349 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Neuroscience. Protein Description: Full Length of Mature Protein.

Specification

• Description: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 52.0 kDa
• Protein length: 26-349 aa
• AA Sequence: GALAPGTPARNLPENHIDLPGPALW TPQASHHRRRGPGKKEWGPGLPSQA QDGAVVTATRQASRLPEAEGLLPEQ SPAGLLQDKDLLLGLALPYPEKENR PPGWERTRKRSREHKRRRDRLRLHQ GRALVRGPSSLMKKAELSEAQVLDA AMEESSTSLAPTMFFLTTFEAAPAT EESLILPVTSLRPQQAQPRSDGEVM PTLDMALFDWTDYEDLKPDGWPSAK KKEKHRGKLSSDGNETSPAEGEPCD HHQDCLPGTCCDLREHLCTPHNRGL NNKCFDDCMCVEGLRCYAKFHRNRR VTRRKGRCVEPETANGDQGSFINV
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: DRAXIN dorsal inhibitory axon guidance protein [ Homo sapiens ]
• Official Symbol: DRAXIN
• Synonyms: UNQ3119; neucrin; AGPA3119; C1orf187
• Gene ID: 374946
• mRNA Refseq: NM_198545.3
• Protein Refseq: NP_940947.3
• MIM: 612682
• UniProt ID: Q8NBI3