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Recombinant Human DUSP8 Protein, GST-tagged

Cat.No. : DUSP8-2947H
Product Overview : Human DUSP8 partial ORF ( NP_004411, 2 a.a. - 109 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 37.62 kDa
AA Sequence : AGDRLPRKVMDAKKLASLLRGGPGG PLVIDSRSFVEYNSWHVLSSVNICC SKLVKRRLQQGKVTIAELIQPAARS QVEATEPQDVVVYDQSTRDASVLAA DSFLSILL
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DUSP8 dual specificity phosphatase 8 [ Homo sapiens ]
Official Symbol : DUSP8
Synonyms : DUSP8; dual specificity phosphatase 8; C11orf81, chromosome 11 open reading frame 81; dual specificity protein phosphatase 8; FLJ42958; H1 phosphatase; vaccinia virus homolog; HB5; HVH 5; serine/threonine specific protein phosphatase; H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase hVH-5; HVH8; HVH-5; C11orf81; FLJ42476;
Gene ID : 1850
mRNA Refseq : NM_004420
Protein Refseq : NP_004411
MIM : 602038
UniProt ID : Q13202

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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