Recombinant Human EBP Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human EBP Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : EBP-6293H
Product Overview : EBP MS Standard C13 and N15-labeled recombinant protein (NP_006570) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : The protein encoded by this gene is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. This protein shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of this protein is its high content of aromatic amino acid residues (>23%) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 26.4 kDa
AA Sequence : MTTNAGPLHP YWPQHLRLDN FVPNDRPTWH ILAGLFSVTG VLVVTTWLLS GRAAVVPLGT WRRLSLCWFA VCGFIHLVIE GWFVLYYEDL LGDQAFLSQL WKEYAKGDSR YILGDNFTVC METITACLWG PLSLWVVIAF LRQHPLRFIL QLVVSVGQIY GDVLYFLTEH RDGFQHGELG HPLYFWFYFV FMNALWLVLP GVLVLDAVKH LTHAQSTLDA KATKAKSKKN TRTRPLEQKL ISEEDLAAND ILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : EBP EBP cholestenol delta-isomerase [ Homo sapiens (human) ]
Official Symbol : EBP
Synonyms : EBP; emopamil binding protein (sterol isomerase); CDPX2, emopamil binding protein (sterol isomerase); 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; 3 beta hydroxysteroid delta 8; delta 7 isomerase; CHO2; Chondrodysplasia punctata 2; X linked dominant (Happle syndrome); CPX; CPXD; sterol 8 isomerase; sterol 8-isomerase; D8-D7 sterol isomerase; cholestenol Delta-isomerase; delta(8)-Delta(7) sterol isomerase; emopamil-binding protein (sterol isomerase); 3-beta-hydroxysteroid-delta-8,delta-7-isomerase; Chondrodysplasia punctata-2, X-linked dominant (Happle syndrome); CDPX2;
Gene ID : 10682
mRNA Refseq : NM_006579
Protein Refseq : NP_006570
MIM : 300205
UniProt ID : Q15125

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