Recombinant Human EGFR Protein, C-6His-Avi tagged, Biotinylated
Cat.No. : | EGFR-07H |
Product Overview : | Biotinylated Recombinant Human Epidermal Growth Factor Receptor/Receptor Tyrosine Protein KinaseErbB1 is produced by our Mammalian expression system and the target gene encoding Leu25-Ser378 is expressed with a 6His, Avi tag at the C-terminus. |
- Specification
- Gene Information
- Related Products
Description : | The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerization and heterodimerization with ErbB2, resulting in cell signaling, heterodimerization tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signaling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumors. Several anti-cancer drugs use EGFR as target. |
Source : | Human Cells |
Species : | Human |
Tag : | C-6His-Avi |
Protein Length : | Leu25-Ser378 |
Endotoxin : | Less than 0.1 ng/μg (1 EU/μg) |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Shipping : | Ambient |
Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens (human) ] |
Official Symbol : | EGFR |
Synonyms : | Epidermal growth factor receptor; EGFR; Proto-oncogene c-ErbB-1; Receptortyrosine-protein kinase erbB-1; EGFR |
Gene ID : | 1956 |
mRNA Refseq : | NM_005228 |
Protein Refseq : | NP_005219 |
MIM : | 131550 |
UniProt ID : | P00533 |
Products Types
◆ Recombinant Protein | ||
EGFR-292E | Active Recombinant Human EGFR Protein, His-tagged | +Inquiry |
EGFR-0976H | Recombinant Human EGFR Protein (L25-A1210), eGFP, Strep II, 10×His tagged | +Inquiry |
EGFR-143E | Recombinant Human EGFR Protein (627 aa), His-tagged | +Inquiry |
EGFR-10H | Recombinant Human EGFR Protein, GST-tagged | +Inquiry |
EGFR-12H | Active Recombinant Human EGFR Protein, His-tagged | +Inquiry |
◆ Lysates | ||
EGFR-663HCL | Recombinant Human EGFR cell lysate | +Inquiry |
EGFR-1462RCL | Recombinant Rat EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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