| Description : |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). |
| Source : |
HEK293 |
| Species : |
Human |
| Form : |
Lyophilized |
| Molecular Mass : |
69.5 kDa |
| Protein Length : |
1210 |
| AA Sequence : |
MRPSGTAGAALLALLAALCPASRAL EEKKVCQGTSNKLTQLGTFEDHFLS LQRMFNNCEVVLGNLEITYVQRNYD LSFLKTIQEVAGYVLIALNTVERIP LENLQIIRGNMYYENSYALAVLSNY DANKTGLKELPMRNLQEILHGAVRF SNNPALCNVESIQWRDIVSSDFLSN MSMDFQNHLGSCQKCDPSCPNGSCW GAGEENCQKLTKIICAQQCSGRCRG KSPSDCCHNQCAAGCTGPRESDCLV CRKFRDEATCKDTCPPLMLYNPTTY QMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACGADSYEMEEDGVRK CKKCEGPCRKVCNGIGIGEFKDSLS INATNIKHFKNCTSISGDLHILPVA FRGDSFTHTPPLDPQELDILKTVKE ITGFLLIQAWPENRTDLHAFENLEI IRGRTKQHGQFSLAVVSLNITSLGL RSLKEISDGDVIISGNKNLCYANTI NWKKLFGTSGQKTKIISNRGENSCK ATGQVCHALCSPEGCWGPEPRDCVS CRNVSRGRECVDKCNLLEGEPREFV ENSECIQCHPECLPQAMNITCTGRG PDNCIQCAHYIDGPHCVKTCPAGVM GENNTLVWKYADAGHVCHLCHPNCT YGCTGPGLEGCPTNGPKIPSIATGM VGALLLLLVVALGIGLFMRRRHIVR KRTLRRLLQERELVEPLTPSGEAPN QALLRILKETEFKKIKVLGSGAFGT VYKGLWIPEGEKVKIPVAIKELREA TSPKANKEILDEAYVMASVDNPHVC RLLGICLTSTVQLITQLMPFGCLLD YVREHKDNIGSQYLLNWCVQIAKGM NYLEDRRLVHRDLAARNVLVKTPQH VKITDFGLAKLLGAEEKEYHAEGGK VPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISS ILEKGERLPQPPICTIDVYMIMVKC WMIDADSRPKFRELIIEFSKMARDP QRYLVIQGDERMHLPSPTDSNFYRA LMDEEDMDDVVDADEYLIPQQGFFS SPSTSRTPLLSSLSATSNNSTVACI DRNGLQSCPIKEDSFLQRYSSDPTG ALTEDSIDDTFLPVPEYINQSVPKR PAGSVQNPVYHNQPLNPAPSRDPHY QDPHSTAVGNPEYLNTVQPTCVNST FDSPAHWAQKGSHQISLDNPDYQQD FFPKEAKPNGIFKGSTAENAEYLRV APQSSEFIGA |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
