Recombinant Human EGFR Protein, His-tagged
Cat.No. : | EGFR-01H |
Product Overview : | Mouse myeloma cell line, NS0-derived human EGFR protein Leu25-Ser378 (Asn273Lys), with a C-terminal 6-His tag. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). |
Source : | NS0 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Molecular Mass : | Predicted Molecular Mass: 39 kDa SDS-PAGE: 65-80 kDa, reducing conditions |
N-terminal Sequence Analysis : | Leu25 |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >95% |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 250 μg/mL in PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens (human) ] |
Official Symbol : | EGFR |
Synonyms : | ERBB; ERRP; HER1; mENA; ERBB1; PIG61; NISBD2 |
Gene ID : | 1956 |
mRNA Refseq : | NM_001346941 |
Protein Refseq : | NP_001333870 |
MIM : | 131550 |
UniProt ID : | P00533 |
Products Types
◆ Lysates | ||
EGFR-1621MCL | Recombinant Mouse EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIt is associated with biological processes in human embryonic development and tissue regeneration.
EGFR inhibits adverse drug reactions such as rash, inflammation, and diarrhea during drug treatment.
The role of EGFR in tumor treatment is to act as a molecular marker and can be used as a prognostic indicator and monitor tumor progression; at the same time, EGFR mutations can also be targeted for targeted therapy.
EGFR gene mutation detection generally uses PCR, fluorescence in situ hybridization, and direct sequencing.
The combination of EGFR inhibitors with chemotherapy drugs, radiotherapy, immunotherapy, etc. can increase the efficacy of treatment and reduce the occurrence of adverse reactions.
EGFR mutations can have a significant impact on the efficacy of targeted therapies, and patients with mutations have higher response rates.
Customer Reviews (3)
Write a reviewThe powerful biological activity of EGFR combined with its high purity makes the experimental results highly reproducible, which is of great significance in the field of scientific research.
Due to the short half-life and high clearance characteristics of EGFR, they can better adapt to the needs of clinical treatment and provide more treatment options for patients.
The production process of EGFR uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and reduces the consumption of human and material resources.
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