Recombinant Human EGLN1 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | EGLN1-4080H |
| Product Overview : | EGLN1 MS Standard C13 and N15-labeled recombinant protein (NP_071334) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 46.5 kDa |
| AA Sequence : | MANDSGGPGG PSPSERDRQY CELCGKMENL LRCSRCRSSF YCCKEHQRQD WKKHKLVCQG SEGALGHGVG PHQHSGPAPP AAVPPPRAGA REPRKAAARR DNASGDAAKG KVKAKPPADP AAAASPCRAA AGGQGSAVAA EAEPGKEEPP ARSSLFQEKA NLYPPSNTPG DALSPGGGLR PNGQTKPLPA LKLALEYIVP CMNKHGICVV DDFLGKETGQ QIGDEVRALH DTGKFTDGQL VSQKSDSSKD IRGDKITWIE GKEPGCETIG LLMSSMDDLI RHCNGKLGSY KINGRTKAMV ACYPGNGTGY VRHVDNPNGD GRCVTCIYYL NKDWDAKVSG GILRIFPEGK AQFADIEPKF DRLLFFWSDR RNPHEVQPAY ATRYAITVWY FDADERARAK VKYLTGEKGV RVELNKPSDS VGKDVFTRTR PLEQKLISEE DLAANDILDY KDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | EGLN1 egl-9 family hypoxia inducible factor 1 [ Homo sapiens (human) ] |
| Official Symbol : | EGLN1 |
| Synonyms : | EGLN1; egl nine homolog 1 (C. elegans); C1orf12, EGL nine (C.elegans) homolog 1; egl nine homolog 1; HIF prolyl hydroxylase 2; HIFPH2; PHD2; SM 20; ZMYND6; egl nine-like protein 1; HIF-prolyl hydroxylase 2; zinc finger MYND domain-containing protein 6; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2; HPH2; SM20; ECYT3; HPH-2; C1orf12; HIF-PH2; DKFZp761F179; |
| Gene ID : | 54583 |
| mRNA Refseq : | NM_022051 |
| Protein Refseq : | NP_071334 |
| MIM : | 606425 |
| UniProt ID : | Q9GZT9 |
◆ Recombinant Protein
| EGLN1-001H | Recombinan Human EGLN1 protein, FLAG-tagged | +Inquiry |
| EGLN1-414H | Recombinant Human EGLN1 Protein, MYC/DDK-tagged | +Inquiry |
| Egln1-497M | Recombinant Mouse Egln1 Protein, MYC/DDK-tagged | +Inquiry |
| EGLN1-12325H | Recombinant Human EGLN1, GST-tagged | +Inquiry |
| EGLN1-126H | Recombinant human EGLN1, GST tagged | +Inquiry |
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◆ Lysates
| EGLN1-6696HCL | Recombinant Human EGLN1 293 Cell Lysate | +Inquiry |
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