Recombinant Human EME1, GST-tagged

• Cat.No.: EME1-12431H
• Product Overview: Recombinant Human EME1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-350a.a.
• Description: This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: EME1 essential meiotic endonuclease 1 homolog 1 (S. pombe) [ Homo sapiens ]
• Official Symbol: EME1
• Synonyms: EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe); crossover junction endonuclease EME1; FLJ31364; MMS4L; SLX2 structure specific endonuclease subunit homolog A (S. cerevisiae); SLX2A; hMMS4; MMS4 homolog; homolog of yeast EME1 endonuclease; essential meiotic endonuclease 1 homolog 2; SLX2 structure-specific endonuclease subunit homolog A
• Gene ID: 146956
• mRNA Refseq: NM_001166131
• Protein Refseq: NP_001159603
• MIM: 610885
• UniProt ID: Q96AY2
• Chromosome Location: 17q21.33
• Pathway: Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Homologous recombination, organism-specific biosystem; Homologous recombination, conserved biosystem
• Function: DNA binding; endonuclease activity; hydrolase activity; metal ion binding; protein binding