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Recombinant Human ENO1 protein, His-tagged

Cat.No. : ENO1-2513H
Product Overview : Recombinant Human ENO1(1-434aa) fused with His tag at N-terminal was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes one of three enolase isoenzymes found in mammals; it encodes alpha-enolase, a homodimeric soluble enzyme, and also encodes a shorter monomeric structural lens protein, tau-crystallin. The two proteins are made from the same message. The full length protein, the isoenzyme, is found in the cytoplasm. The shorter protein is produced from an alternative translation start, is localized to the nucleus, and has been found to bind to an element in the c-myc promoter. A pseudogene has been identified that is located on the other arm of the same chromosome.
Source : HEK293
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Protein length : 1-434aa
AA Sequence : SILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV VIGMDVAASE FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV TESLQACKLA QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK
Purity : >90% ( SDS-PAGE )
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade.
Gene Name : ENO1 enolase 1, (alpha) [ Homo sapiens ]
Official Symbol : ENO1
Synonyms : ENO1; enolase 1, (alpha); ENO1L1, MPB1; alpha-enolase; c-myc promoter-binding protein-1; MBP 1; PPH; alpha-enolase; enolase-alpha; tau-crystallin; non-neural enolase; alpha enolase like 1; phosphopyruvate hydratase; plasminogen-binding protein; MYC promoter-binding protein 1; 2-phospho-D-glycerate hydro-lyase; NNE; MPB1; ENO1L1;
Gene ID : 2023
mRNA Refseq : NM_001201483
Protein Refseq : NP_001188412
MIM : 172430
UniProt ID : P06733
Chromosome Location : 1p36.2
Pathway : Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem; Glucose metabolism, organism-specific biosystem; Glycolysis, organism-specific biosystem;
Function : DNA binding; lyase activity; magnesium ion binding; phosphopyruvate hydratase activity; protein binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some of the cancers where ENO1 is overexpressed? 11/26/2022

ENO1 overexpression is seen in cancers like lung cancer, breast cancer, pancreatic cancer, and glioblastoma, among others.

Are there any diagnostic or therapeutic applications for ENO1 in infectious diseases? 04/17/2021

ENO1 in infectious agents may offer potential targets for diagnostic tests and treatments, although this field of research is still developing.

Are there any targeted therapies that focus on ENO1 in cancer treatment? 12/21/2018

Some research suggests that targeted therapies directed at ENO1 could be a potential strategy for cancer treatment, but more studies are needed.

Can ENO1 be used as a diagnostic marker for autoimmune diseases? 11/29/2016

ENO1 antibodies can be used as diagnostic markers for autoimmune diseases like celiac disease.

Are there diagnostic applications for ENO1 in neurodegenerative diseases? 10/09/2016

ENO1 may serve as a potential biomarker for the early diagnosis and monitoring of neurodegenerative diseases, although more research is needed.

Customer Reviews (3)

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Reviews
07/24/2021

    Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

    03/30/2021

      the use of ENO1 protein in my research offers significant advantages in detecting cell death processes and investigating coagulation and thrombosis mechanisms.

      06/25/2020

        The manufacturer of ENO1 protein plays a crucial role in supporting my research endeavors.

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