Recombinant Human EPHA8 Protein (A2-L1005), GST tagged

• Cat.No.: EPHA8-0982H
• Product Overview: Recombinant Human GST-TEV-GG-EPHA8(A2-L1005 end) Protein was expressed in Insect cell.

Specification

• Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.
• Source: Insect cell
• Species: Human
• Tag: GST
• Form: Liquid
• Protein Length: A2-L1005
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: EPHA8 EPH receptor A8 [ Homo sapiens (human) ]
• Official Symbol: EPHA8
• Synonyms: EPHA8; EPH receptor A8; EEK, EphA8; ephrin type-A receptor 8; Hek3; EPH-like kinase 3; tyrosylprotein kinase; protein-tyrosine kinase; hydroxyaryl-protein kinase; EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; tyrosine-protein kinase receptor EEK; EEK; EK3; HEK3; KIAA1459
• Gene ID: 2046
• mRNA Refseq: NM_001006943
• Protein Refseq: NP_001006944
• MIM: 176945
• UniProt ID: P29322