Recombinant Human ERCC6L Protein, GST-tagged

• Cat.No.: ERCC6L-3462H
• Product Overview: Human ERCC6L full-length ORF ( AAH08808, 1 a.a. - 419 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 71.61 kDa
• AA Sequence: MEKSFATKNEAVQKETLQEGPKQEA LQEDPLESFNYVLSKSTKADIGPNL DQLKDDEILRHCNPWPIISITNESQ NAESNVSIIEIADDLSASHSALQDA QASEAKLEEEPSASSPQYACDFNLF LEDSADNRQNFSSQSLEHVEKENSL CGSAPNSRAGFVHSKTCLSWEFSEK DDEPEEVVVKAKIRSKARRIVSDGE DEDDSFKDTSSINPFNTSLFQFSSV KQFDASTPKNDISPPGRFFSSQIPS SVNKSMNSRRSLASRRSLINMVLDH VEDMEERLDDSSEAKGPEDYPEEGV EESSGEASKYTEEDPSGETLSSENK SSWLMTSKPSALAQETSLGAPEPLS GEQLVGSPQDKAAEATNDYETLVKR GKELKECGKIQEALNCLVKALDIKS ADPEVMLLTLSLYKQLNNN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ERCC6L excision repair cross-complementing rodent repair deficiency, complementation group 6-like [ Homo sapiens ]
• Official Symbol: ERCC6L
• Synonyms: ERCC6L; excision repair cross-complementing rodent repair deficiency, complementation group 6-like; DNA excision repair protein ERCC-6-like; FLJ20105; PICH; PLK1 interacting checkpoint helicase; tumor antigen BJ-HCC-15; SNF2/RAD54 family protein; ATP-dependent helicase ERCC6-like; excision repair protein ERCC6-like; Plk1-interacting checkpoint helicase; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; MGC131695
• Gene ID: 54821
• mRNA Refseq: NM_017669
• Protein Refseq: NP_060139
• MIM: 300687
• UniProt ID: Q2NKX8