Recombinant Human ERLIN2 Protein, GST-tagged

• Cat.No.: ERLIN2-3479H
• Product Overview: Human ERLIN2 full-length ORF ( NP_009106.1, 1 a.a. - 339 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: GST
• Description: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
• Molecular Mass: 64.2 kDa
• AA Sequence: MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLADKLSFGLEDEPLETATKEN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ERLIN2 ER lipid raft associated 2 [ Homo sapiens ]
• Official Symbol: ERLIN2
• Synonyms: ERLIN2; ER lipid raft associated 2; C8orf2, chromosome 8 open reading frame 2 , Erlin 2, SPFH domain family, member 2 , SPFH2; erlin-2; NET32; SPFH domain family, member 2; endoplasmic reticulum lipid raft-associated protein 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; SPFH2; SPG18; C8orf2; Erlin-2; MGC87072
• Gene ID: 11160
• mRNA Refseq: NM_001003790
• Protein Refseq: NP_001003790
• MIM: 611605
• UniProt ID: O94905