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Recombinant Human ETF1 protein, MYC/DDK-tagged

Cat.No. : ETF1-5893H
Product Overview : Recombinant Human ETF1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 48.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ETF1 eukaryotic translation termination factor 1 [ Homo sapiens ]
Official Symbol : ETF1
Synonyms : ETF1; eukaryotic translation termination factor 1; ERF, ERF1, SUP45L1; eukaryotic peptide chain release factor subunit 1; eRF1; polypeptide chain release factor 1; RF1; sup45 (yeast omnipotent suppressor 45) homolog like 1; TB3 1; protein Cl1; eukaryotic release factor 1; sup45 (yeast omnipotent suppressor 45) homolog-like 1; ERF; ERF1; TB3-1; D5S1995; SUP45L1; MGC111066;
Gene ID : 2107
mRNA Refseq : NM_004730
Protein Refseq : NP_004721
MIM : 600285
UniProt ID : P62495
Chromosome Location : 5q31.2
Pathway : Eukaryotic Translation Termination, organism-specific biosystem; Gene Expression, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Nonsense Mediated Decay Enhanced by the Exon Junction Complex, organism-specific biosystem; Nonsense Mediated Decay Independent of the Exon Junction Complex, organism-specific biosystem; Nonsense-Mediated Decay, organism-specific biosystem; Translation, organism-specific biosystem;
Function : RNA binding; protein binding; ribosome binding; translation release factor activity; translation release factor activity, codon specific; translation termination factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials related to ETF1 protein disorders? 04/25/2023

There may be clinical trials evaluating potential treatments or interventions for ETF1 protein disorders, and individuals and families affected by these disorders can consider participating in such trials.

What are the symptoms of metabolic disorders caused by ETF1 protein dysfunction? 06/18/2022

Symptoms may include muscle weakness, lethargy, hypoglycemia, metabolic acidosis, and in some cases, developmental delays and neurological symptoms.

Can ETF1 protein disorders be detected before birth? 05/15/2019

Yes, prenatal testing through genetic screening can detect mutations in the ETF1 gene, allowing for early intervention and management.

How are ETF1 protein disorders diagnosed? 07/05/2018

Diagnosis typically involves biochemical testing, genetic testing, and metabolic screening to identify abnormalities in fatty acid metabolism.

Can ETF1 protein disorders affect individuals of all ages? 02/09/2017

Yes, ETF1 protein disorders can affect individuals of all ages, from newborns to adults, and may present with different symptoms at different stages of life.

Customer Reviews (3)

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Reviews
11/25/2022

    What sets this protein apart is the outstanding technical support provided by the manufacturer.

    09/20/2022

      Its versatility allows me to explore its diverse roles in various biochemical and biological processes accurately.

      07/18/2019

        The ETF1 Protein is of exceptional quality and is precisely tailored to meet my experimental requirements.

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