| Description : |
The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
93.6 kDa |
| AA Sequence : |
MAENSESLGTVPEHERILQEIESTD TACVGPTLRSVYDDQPNAHKKFMEK LDACIRNHDKEIEKMCNFHHQGFVD AITELLKVRTDAEKLKVQVTDTNRR FQDAGKEVIVHTEDIIRCRIQQRNI TTVVEKLQLCLPVLEMYSKLKEQMS AKRYYSALKTMEQLENVYFPWVSQY RFCQLMIENLPKLREDIKEISMSDL KDFLESIRKHSDKIGETAMKQAQHQ KTFSVSLQKQNKMKFGKNMYINRDR IPEERNETVLKHSLEEEDENEEEIL TVQDLVDFSPVYRCLHIYSVLGDEE TFENYYRKQRKKQARLVLQPQSNMH ETVDGYRRYFTQIVGFFVVEDHILH VTQGLVTRAYTDELWNMALSKIIAV LRAHSSYCTDPDLVLELKNLIVIFA DTLQGYGFPVNRLFDLLFEIRDQYN ETLLKKWAGVFRDIFEEDNYSPIPV VNEEEYKIVISKFPFQDPDLEKQSF PKKFPMSQSVPHIYIQVKEFIYASL KFSESLHRSSTEIDDMLRKSTNLLL TRTLSSCLLNLIRKPHIGLTELVQI IINTTHLEQACKYLEDFITNITNIS QETVHTTRLYGLSTFKDARHAAEGE IYTKLNQKIDEFVQLADYDWTMSEP DGRASGYLMDLINFLRSIFQVFTHL PGKVAQTACMSACQHLSTSLMQMLL DSELKQISMGAVQQFNLDVIQCELF ASSEPVPGFQGDTLQLAFIDLRQLL DLFMVWDWSTYLADYGQPASKYLRV NPNTALTLLEKMKDTSKKNNIFAQF GKNDRDKQKLIETVVKQLRSLVNGM SQHMTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
