Recombinant Human EYA4 Protein, GST-tagged

• Cat.No.: EYA4-3595H
• Product Overview: Human EYA4 full-length ORF ( NP_742101.2, 1 a.a. - 616 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator through its protein phosphatase activity, and it may be important for eye development, and for continued function of the mature organ of Corti. Mutations in this gene are associated with postlingual, progressive, autosomal dominant hearing loss at the deafness, autosomal dominant non-syndromic sensorineural 10 locus. The encoded protein is also a putative oncogene that mediates DNA repair, apoptosis, and innate immunity following DNA damage, cellular damage, and viral attack. Defects in this gene are also associated with dilated cardiomyopathy 1J. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 93.5 kDa
• AA Sequence: MEDSQDLNEQSVKKTCTESDVSQSQ NSRSMEMQDLASPHTLVGGGDTPGS SKLEKSNLSSTSVTTNGTGVSLLAV KTEPLNSSETTATTGDGALDTFTGS VITSSGYSPRSAHQYSPQLYPSKPY PHILSTPAAQTMSAYAGQTQYSGMQ QPAVYTAYSQTGQPYSLPTYDLGVM LPAIKTESGLSQTQSPLQSGCLSYS PGFSTPQPGQTPYSYQMPGSSFAPS STIYANNSVSNSTNFSGSQQDYPSY TAFGQNQYAQYYSASTYGAYMTSNN TADGTPSSTSTYQLQESLPGLTNQP GEFDTMQSPSTPIKDLDERTCRSSG SKSRGRGRKNNPSPPPDSDLERVFV WDLDETIIVFHSLLTGSYAQKYGKD PPMAVTLGLRMEEMIFNLADTHLFF NDLEECDQVHIDDVSSDDNGQDLST YSFATDGFHAAASSANLCLPTGVRG GVDWMRKLAFRYRRVKELYNTYKNN VGGLLGPAKRDAWLQLRAEIEGLTD SWLTNALKSLSIISTRSNCINVLVT TTQLIPALAKVLLYSLGGAFPIENI YSATKIGKESCFERIMQRFGRKVVY VVIGDGVEEEQAAKKHNMPFWRISS HSDLLALHQALELEYL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: EYA4 eyes absent homolog 4 (Drosophila) [ Homo sapiens ]
• Official Symbol: EYA4
• Synonyms: EYA4; eyes absent homolog 4 (Drosophila); CMD1J, DFNA10, eyes absent (Drosophila) homolog 4; eyes absent homolog 4; dJ78N10.1 (eyes absent); CMD1J; DFNA10
• Gene ID: 2070
• mRNA Refseq: NM_004100
• Protein Refseq: NP_004091
• MIM: 603550
• UniProt ID: O95677