Recombinant Human EZH1, His-tagged

• Cat.No.: EZH1-12612H
• Product Overview: Recombinant Human EZH1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 161-267a.a.
• Description: EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: EZH1 enhancer of zeste homolog 1 (Drosophila) [ Homo sapiens ]
• Official Symbol: EZH1
• Synonyms: EZH1; enhancer of zeste homolog 1 (Drosophila); enhancer of zeste (Drosophila) homolog 1; histone-lysine N-methyltransferase EZH1; KIAA0388; KMT6B; ENX-2
• Gene ID: 2145
• mRNA Refseq: NM_001991
• Protein Refseq: NP_001982
• MIM: 601674
• UniProt ID: Q92800
• Chromosome Location: 17q21.1-q21.3
• Function: DNA binding; chromatin binding; histone methyltransferase activity (H3-K27 specific); methyltransferase activity; transferase activity