Recombinant Human Ezrin, His-tagged

• Cat.No.: EZR-516H
• Product Overview: Recombinant Human Ezrin,encoding the mature form of human EZR(Pro2-Leu586) was expressed with a his tag at the N-terminus.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 2-586 a.a.
• Description: The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.
• Molecular Mass: The recombinant human EZR consists of 601 amino acids and predicts a molecular mass of 71.2 KDa. It migrates as an approximately 82 KDa band in SDS-PAGE under reducing conditions.
• Predicted N terminal: His
• Formulation: Lyophilized from a 0.2μm filtered solution of PBS 100mM Arg 10% glycerol, 0.1%Twen 20, pH 7.5.
• Purity: Greater than 60% as determined by SDS-PAGE
• Stability: Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: EZR ezrin [ Homo sapiens ]
• Official Symbol: EZR
• Synonyms: EZR; ezrin; VIL2, villin 2 (ezrin); cytovillin 2 CVL; CVIL; ezrin; p81; villin-2; cytovillin 2
• Gene ID: 7430
• mRNA Refseq: NM_001111077
• Protein Refseq: NP_001104547
• MIM: 123900
• UniProt ID: P15311
• Chromosome Location: 6q25.3
• Pathway: Axon guidance; Developmental Biology; Gastric acid secretion
• Function: actin filament binding; cell adhesion molecule binding ; protein binding