Recombinant Human F13A1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | F13A1-1890H |
Product Overview : | F13A1 MS Standard C13 and N15-labeled recombinant protein (NP_000120) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 83.3 kDa |
AA Sequence : | MSETSRTAFGGRRAVPPNNSNAAED DLPTVELQGVVPRGVNLQEFLNVTS VHLFKERWDTNKVDHHTDKYENNKL IVRRGQSFYVQIDFSRPYDPRRDLF RVEYVIGRYPQENKGTYIPVPIVSE LQSGKWGAKIVMREDRSVRLSIQSS PKCIVGKFRMYVAVWTPYGVLRTSR NPETDTYILFNPWCEDDAVYLDNEK EREEYVLNDIGVIFYGEVNDIKTRS WSYGQFEDGILDTCLYVMDRAQMDL SGRGNPIKVSRVGSAMVNAKDDEGV LVGSWDNIYAYGVPPSAWTGSVDIL LEYRSSENPVRYGQCWVFAGVFNTF LRCLGIPARIVTNYFSAHDNDANLQ MDIFLEEDGNVNSKLTKDSVWNYHC WNEAWMTRPDLPVGFGGWQAVDSTP QENSDGMYRCGPASVQAIKHGHVCF QFDAPFVFAEVNSDLIYITAKKDGT HVVENVDATHIGKLIVTKQIGGDGM MDITDTYKFQEGQEEERLALETALM YGAKKPLNTEGVMKSRSNVDMDFEV ENAVLGKDFKLSITFRNNSHNRYTI TAYLSANITFYTGVPKAEFKKETFD VTLEPLSFKKEAVLIQAGEYMGQLL EQASLHFFVTARINETRDVLAKQKS TVLTIPEIIIKVRGTQVVGSDMTVI VEFTNPLKETLRNVWVHLDGPGVTR PMKKMFREIRPNSTVQWEEVCRPWV SGHRKLIASMSSDSLRHVYGELDVQ IQRRPSMTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | F13A1 coagulation factor XIII A chain [ Homo sapiens (human) ] |
Official Symbol : | F13A1 |
Synonyms : | F13A1; coagulation factor XIII, A1 polypeptide; F13A; coagulation factor XIII A chain; TGase; factor XIIIa; fibrinoligase; FSF, A subunit; coagulation factor XIIIa; transglutaminase A chain; transglutaminase. plasma; fibrin stabilizing factor, A subunit; coagulation factor XIII, A polypeptide; protein-glutamine gamma-glutamyltransferase A chain; bA525O21.1 (coagulation factor XIII, A1 polypeptide); |
Gene ID : | 2162 |
mRNA Refseq : | NM_000129 |
Protein Refseq : | NP_000120 |
MIM : | 134570 |
UniProt ID : | P00488 |
Products Types
◆ Recombinant Protein | ||
F13a1-2900M | Recombinant Mouse F13a1 Protein, Myc/DDK-tagged | +Inquiry |
F13A1-1332H | Recombinant Human F13A1 Protein, His-tagged | +Inquiry |
F13A1-3609H | Recombinant Human F13A1 Protein, GST-tagged | +Inquiry |
F13A1-2497H | Recombinant Human F13A1 protein(431-520 aa), C-His-tagged | +Inquiry |
F13A1-881H | Recombinant Human F13A1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
F13A1-5399H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
F13A1-1881H | Native Human Coagulation Factor XIII, A1 Polypeptide | +Inquiry |
F13A1-28806TH | Native Human F13A1 | +Inquiry |
◆ Lysates | ||
F13A1-6485HCL | Recombinant Human F13A1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionF13A1 crosslinks fibrin chains, enhancing the stability and resistance of fibrin clots to breakdown.
Yes, F13A1 deficiency can be inherited, with autosomal recessive inheritance being the most common pattern.
Treatment may involve F13A1 replacement therapy or transfusions of plasma rich in F13A1.
F13A1 levels are sometimes used as a biomarker to assess the risk of bleeding or thrombotic events in certain clinical conditions.
Some studies suggest that altered F13A1 levels may be associated with an increased risk of certain cardiovascular diseases.
Customer Reviews (3)
Write a reviewThe protein's unique properties allow researchers to gain insights into the underlying mechanisms and explore potential therapeutic interventions.
They continuously invest in research and development, ensuring that their offerings remain at the forefront of scientific advancements.
With the IGF2R protein and the manufacturer's assistance, my trials have been empowered to yield impactful findings, contributing to advancements in the field of biomedical research.
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