Recombinant Human FBXW12 Protein, GST-tagged

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Recombinant Human FBXW12 Protein, GST-tagged

FBXW12 Related Products

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Cat.No. : FBXW12-3968H
Product Overview : Human FBXW12 full-length ORF ( AAI01306.1, 1 a.a. - 445 a.a.) recombinant protein with GST-tag at N-terminal.
Description : Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 77.2 kDa
AA Sequence : MSPTHQIQDP KHWNRIADSD YLWRSLSLQR WDCSNFTNQH LGTHTWKQFF LHQRRKELRL ALAQPHNFIY KVTKNIAFET ELAYLSGNRL TVDEQEKSII CSVSPKQELC AWDVQEGTMI WSSPVQEFHF SNLVTLPQMH LAITMDRKKT IKVWNCQDRD ALAVLPMPQP CYCMEAYLTK DGPFLMVGDA AGDIYTFTLP GLRDVSKVTA FQYGIVLLHC SPDKKWVFAC GTYSRTLPQV FLTESLLRPS EGSDPLSTLL PHKLCASACW TPKVKNRITL MSQSSTGKKT EFITFDLTTK KTGGQTVIQA YEIASFQVAA HLKCPIWMGA SDGYMIVFTS GPYLLLFSIT GFLLQRFEDH QAAINNFWVD PCYVLTTSEN SVHVYMWEEG GRHPYLRSCC HLENTWHDHT TDSCISSVMC DNASIVLRVR KVSDSSILVM YSLNT
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : FBXW12 F-box and WD repeat domain containing 12 [ Homo sapiens ]
Official Symbol : FBXW12
Synonyms : FBXW12; F-box and WD repeat domain containing 12; F box and WD 40 domain protein 12 , F box only protein 35 , FBXO35; F-box/WD repeat-containing protein 12; Fbw12; F-box only protein 35; F-box and WD-40 domain protein 12; F-box- and WD40-repeat-containing protein; F-box and WD-40 domain-containing protein 12; FBW12; FBXO12; FBXO35; MGC120385; MGC120386; MGC120387;
Gene ID : 285231
mRNA Refseq : NM_001159927
Protein Refseq : NP_001153399
MIM : 609075
UniProt ID : Q6X9E4

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