Recombinant Human FCER1A Protein (Met1-Gln205)

• Cat.No.: FCER1A-567H
• Product Overview: Recombinant Human FCER1A Protein (NP_001992.1) (Met1-Gln205) was produced by HEK293 Cells expression system.

Specification

• Description: FcERI, also known as FCER1A, is the alpha subunit of the immunoglobulin epsilon receptor (IgE receptor). IgE receptor is a high affinity IgE receptor which plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. IgE receptor is comprised of an alpha subunit(FcERI), a beta subunit, and two gamma subunits. FcERI is glycosylated and contains 2 Ig-like (immunoglobulin-like) domains.
• Source: HEK293
• Species: Human
• Predicted N Terminal: Val 26
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant human FCER1A consists of 180 amino acids and predicts a molecular mass of 21 kDa.
• Protein length: Met1-Gln205
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Tag: Non

Gene Information

• Gene Name: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens ]
• Official Symbol: FCER1A
• Synonyms: FCER1A; alpha polypeptide; FCE1A; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; FcERI
• Gene ID: 2205
• mRNA Refseq: NM_002001
• Protein Refseq: NP_001992
• MIM: 147140
• UniProt ID: P12319

Reviews

11/30/2022

FCER1A can maintain its biological activity and structural integrity under specific experimental conditions.

11/08/2022

FCER1A quality is stable and reliable, with no significant differences between batches.

01/15/2021

FCER1A has high chemical and physical stability and is suitable for long-term storage and use.

Q&As

Is FCER1A expression regulated?

Modulation of FCER1A expression can be achieved through techniques such as gene knockout, gene silencing, or gene transduction. In addition, its expression levels can also be affected by altering environmental factors such as nutrition, inflammation, etc.

How can I detect the expression level of FCER1A?

The expression level of FCER1A can be detected by gene expression profiling or immunohistochemistry.

Is there a role for FCER1A in the immune system?

FCER1A plays a key role in the immune system, recognizing and presenting antigens to T cell receptors, thereby initiating an adaptive immune response.

What diseases is FCER1A associated with?

Studies have shown that FCER1A is associated with the risk of some autoimmune diseases, inflammatory diseases, and certain cancers.

What is the significance of studying FCER1A?

Studying FCER1A can help to gain insight into the mechanisms of immune response and inflammatory response, which is of great significance for the development of new drugs and therapeutic strategies. In addition, it is also of great value for understanding the pathogenesis and prevention of diseases.

How is FCER1A related to other genes or proteins?

FCER1A has complex associations with other genes and proteins, such as its interaction with T cell receptors, inflammatory factors, etc.