Active Recombinant Human FCGR3A Protein, His-tagged
Cat.No. : | FCGR3A-626H |
Product Overview : | Human FCGR3A / CD16a (V158) Protein,also called Human FCGR3A / CD16a Protein (176 Val), Gly 17 - Gln 208 (Accession # AAH17865.1), was produced in human 293 cells (HEK293). |
- Specification
- Gene Information
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Gly 17 |
Form : | Lyophilized from sterile PBS, pH7.4, 10% Trehalose. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized Yervoy Ipilimumab (Human IgG1) at 5 μg/mL (100 μL/well) can bind Human FCGR3A / CD16a (V158), His Tag with a linear range of 1-16 ng/mL. The bioactivity is measured by its binding ability to Ipilimumab in a SPR assay. Immobilized Human FCGR3A / CD16a (V158), His Tag can bind Ipilimumab with affinity constant of around 171 nM. |
Molecular Mass : | Human FCGR3A / CD16a (V158), His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 23.7 kDa. The reducing protein migrates as 40-50 kDa in SDS-PAGE due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [ Homo sapiens ] |
Official Symbol : | FCGR3A |
Synonyms : | FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIa, receptor for (CD16) , FCG3, FCGR3; low affinity immunoglobulin gamma Fc region receptor III-A; CD16; CD16a; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16); FCG3; CD16A; FCGR3; IGFR3; FCR-10; FCRIII; FCGRIII; FCRIIIA; |
Gene ID : | 2214 |
mRNA Refseq : | NM_000569 |
Protein Refseq : | NP_000560 |
MIM : | 146740 |
UniProt ID : | P08637 |
Chromosome Location : | 1q23 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; Immune System, organism-specific biosystem; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem; Leishmaniasis, organism-specific biosystem; Leishmaniasis, conserved biosystem; |
Function : | IgG binding; receptor activity; |
Products Types
◆ Recombinant Protein | ||
FCGR3A-7288H | Active Recombinant Human FCGR3A protein, His-tagged, 176 Val | +Inquiry |
FCGR3A-3996H | Recombinant Human FCGR3A Protein, GST-tagged | +Inquiry |
FCGR3A-546H | Recombinant Human FCGR3A Protein (F176) | +Inquiry |
FCGR3A-71H | Recombinant Human FCGR3A Protein (ECD), His-tagged(C-ter) | +Inquiry |
FCGR3A-901H | Recombinant Human FCGR3A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FCGR3A-1969RCL | Recombinant Rat FCGR3A cell lysate | +Inquiry |
FCGR3A-001HCL | Recombinant Human FCGR3A cell lysate | +Inquiry |
FCGR3A-1999HCL | Recombinant Human FCGR3A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionFCGR3A activates immune cells and mediates phagocytosis, aiding in the clearance of pathogens and antibody-coated targets.
FCGR3A is key in antibody-dependent cellular cytotoxicity, crucial for the effectiveness of certain cancer immunotherapies.
Genetic variations in FCGR3A influence responses to monoclonal antibody treatments, affecting treatment efficacy.
FCGR3A helps regulate the immune system's balance between activation and tolerance, preventing overactive immune responses.
Changes in FCGR3A function or expression can influence vaccine efficacy, impacting immune system responses to vaccination.
FCGR3A plays a role in the inflammatory response to infections, contributing to pathogen clearance and immune regulation.
FCGR3A expression impacts the development and severity of autoimmune diseases by modulating immune responses.
Customer Reviews (3)
Write a reviewOutstanding protein-protein interaction studies, boosts our experiments.
Swift protein quantification, improves data reliability.
Expertise in peptide synthesis, accelerates our peptide-based projects.
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