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Recombinant Human FCGR3A protein(R167) , His-Avi-tagged

Cat.No. : FCGR3A-142H
Product Overview : Recombinant Human Fc gamma RIIA/CD32a (R167) Protein is expressed from mammalian with a His and Avi tag at the C-terminal. It contains Ala 36 - Ile 218.
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Description : The Fc gamma Rs have been divided into three classes based on close relationships in their extracellular domains; these groups are designated Fc gamma RI (also known as CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. The CD64 proteins are high affinity receptors (~10e-8-10e-9 M) capable of binding monomeric IgG, whereas the CD16 and CD32 proteins bind IgG with lower affinities (~10e-6-10e-7 M) only recognizing IgG aggregates surrounding multivalent antigens.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The Protein has a calculated MW of 23.2kDa .As a result of glycosylation, the protein migrates as 34-40kDa based on Bis-Tris PAGE.
Protein length : It contains Ala 36 - Ile 218 .
Endotoxin : Less than 0.01EU per ug by the LAL method.
Purity : > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [ Homo sapiens ]
Official Symbol : FCGR3A
Synonyms : CD32 antigen; CD32a; CD32MGC23887; CDw32fc-gamma-RIIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc fragment of IgG, low affinity IIa, receptor for (CD32); Fc gamma RIIA; FCG2; Fc-gamma RII-a; Fc-gamma-RIIa; FcGR; FCGR2; FCGR2A; FCGR2A1; FcgRIIA; FCRIIA; fcRII-a; IGFR2MGC30032; IgG Fc receptor II-a; Immunoglobulin G Fc receptor II; low affinity immunoglobulin gamma Fc region receptor II-a
Gene ID : 2214
mRNA Refseq : NM_000569
Protein Refseq : NP_000560
MIM : 146740
UniProt ID : P08637

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does FCGR3A mediate immune cell activation and phagocytosis in response to antibody-opsonized targets? 07/29/2022

FCGR3A activates immune cells and mediates phagocytosis, aiding in the clearance of pathogens and antibody-coated targets.

What role does FCGR3A play in antibody-dependent cellular cytotoxicity, particularly in cancer immunotherapy? 03/03/2020

FCGR3A is key in antibody-dependent cellular cytotoxicity, crucial for the effectiveness of certain cancer immunotherapies.

How does genetic variation in the FCGR3A gene affect individual responses to monoclonal antibody treatments? 12/29/2018

Genetic variations in FCGR3A influence responses to monoclonal antibody treatments, affecting treatment efficacy.

What are the mechanisms by which FCGR3A regulates the balance between immune activation and tolerance? 12/06/2018

FCGR3A helps regulate the immune system's balance between activation and tolerance, preventing overactive immune responses.

How do alterations in FCGR3A expression or function affect the efficacy of vaccines? 08/12/2018

Changes in FCGR3A function or expression can influence vaccine efficacy, impacting immune system responses to vaccination.

How does FCGR3A contribute to the inflammatory response in infectious diseases? 01/25/2018

FCGR3A plays a role in the inflammatory response to infections, contributing to pathogen clearance and immune regulation.

What is the impact of FCGR3A expression on the development and severity of autoimmune diseases? 01/08/2018

FCGR3A expression impacts the development and severity of autoimmune diseases by modulating immune responses.

Customer Reviews (3)

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Reviews
12/28/2021

    Outstanding protein-protein interaction studies, boosts our experiments.

    02/04/2021

      Swift protein quantification, improves data reliability.

      11/21/2019

        Expertise in peptide synthesis, accelerates our peptide-based projects.

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