Recombinant Human FGFR1, GST-tagged, Active

• Cat.No.: FGFR1-312H
• Product Overview: Recombinant human FGFR1 (399-822) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=73kDa.

Specification

• Cat. No.: FGFR1-312H
• Description: FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body.
• Source: Sf9 insect cellsusing baculovirus.
• Sequence: 399-822.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70^oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens ]
• Synonyms: FGFR1; fibroblast growth factor receptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM; FLJ99988; fms-related tyrosine kinase 2; H2; H3; H4; H5; N-SAM; CD331; Pfeiffer syndrome; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2; c-fgr; CD_antigen; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OTTHUMP00000190874; OTTHUMP00000190878; OTTHUMP00000190879; c-fgr; soluble FGFR1 variant 2
• Gene ID: 2260
• mRNA Refseq: NM_015850
• Protein Refseq: NP_056934
• MIM: 136350
• UniProt ID: P11362
• Chromosome Location: 8p11.2-p11.1
• Pathway: MAPK signaling pathway; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton; Axon guidance; Signaling by FGFR
• Function: ATP binding; fibroblast growth factor receptor activity; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; receptor activity; transferase activity