Recombinant Human FGFR1 Protein, His-tagged
Cat.No. : | FGFR1-034H |
Product Overview : | Recombinant Human FGFR1 Protein with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling. The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | ~48 kDa |
AA Sequence : | RPSPTLPEQAQPWGAPVEVESFLVH PGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADS GLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKP NRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKE FKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLD VVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVN GSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNS IGLSHHSAWLTVLEALEERPAVMTS PLYLE |
Purity : | Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
Notes : | For research use only, not for use in diagnostic procedure. |
Storage : | Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
Concentration : | ≥0.5 mg/mL |
Storage Buffer : | PBS, 4M Urea, pH7.4 |
Gene Name : | FGFR1 fibroblast growth factor receptor 1 [ Homo sapiens (human) ] |
Official Symbol : | FGFR1 |
Synonyms : | FGFR1; fibroblast growth factor receptor 1; FLT2, fms related tyrosine kinase 2 , KAL2; BFGFR; CD331; CEK; FLG; H2; H3; H4; H5; N SAM; Pfeiffer syndrome; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1; OGD; FLT2; KAL2; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; bFGF-R-1; FLJ99988; |
Gene ID : | 2260 |
mRNA Refseq : | NM_001174063 |
Protein Refseq : | NP_001167534 |
MIM : | 136350 |
UniProt ID : | P11362 |
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◆ Lysates | ||
FGFR1-476HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
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FGFR1-2765HCL | Recombinant Human FGFR1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1590 | FGFR1 Functional Assay Kit | +Inquiry |
Kit-1557 | U2OS FGFR1 Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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