Recombinant Human FGFR3 protein, His-Avi-tagged

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Recombinant Human FGFR3 protein, His-Avi-tagged

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Cat.No. : FGFR3-093H
Product Overview : Recombinant Human FGFR3 bata (IIIb) Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Asp127-Gly375.
Description : Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Source : HEK293
Species : Human
Tag : His-Avi
Form : Supplied as 0.22um filtered solution in PBS (pH 7.4).
Molecular Mass : The protein has a predicted MW of 30.5 KDa. Due to glycosylation, the protein migrates to 40-55KDa based on Bis-Tris PAGE result
Protein length : It contains Asp127-Gly375 .
Endotoxin : Less than 0.05 EU per ug by the LAL method.
Purity : > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Storage : The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Tris-Bis PAGE :

HPLC data :

Gene Name : FGFR3 fibroblast growth factor receptor 3 [ Homo sapiens ]
Official Symbol : FGFR3
Synonyms : CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism
Gene ID : 2261
mRNA Refseq : NM_000142
Protein Refseq : NP_000133
MIM : 134934
UniProt ID : P22607

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