Recombinant Human FGG, His-tagged

• Cat.No.: FGG-12884H
• Product Overview: Recombinant Human FGG protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-348a.a.
• Description: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FGG fibrinogen gamma chain [ Homo sapiens ]
• Official Symbol: FGG
• Synonyms: FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide
• Gene ID: 2266
• mRNA Refseq: NM_000509
• Protein Refseq: NP_000500
• MIM: 134850
• UniProt ID: P02679
• Chromosome Location: 4q28
• Pathway: Blood Clotting Cascade, organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; GRB2:SOS provides linkage to MAPK signaling for Intergrins, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem
• Function: eukaryotic cell surface binding; protein binding, bridging; receptor binding