Recombinant Human FGL1 protein, His-tagged
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|Product Overview :||Recombinant Human FGL1 protein (Leu23-Ile312) was fused to His-tag at N-terminus and expressed in human 293 cells (HEK293).|
|Description :||Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1. The protective effect of fibrinogen-like protein 1 (FGL1) in liver injury has previously been reported. However, studies have shown that FGL1 may be a predictor of GC patients and a target for GC therapy. Immunocytochemical studies revealed that fgl1 selectively binds to defective spermatozoa in the cauda epididymidis. Northern blot analysis and in situ hybridization demonstrated the high expression of fgl1 in the principal cells of the proximal cauda epididymidis. Immunofluorescence analysis using mouse fibrotic lung tissues suggested that fibrotic regions showed increased expressions of Gtse1 and Fgl1, Gtse1 and Fgl1 are suggested to be novel targets for radiation-induced lung fibrosis.|
|Form :||Lyophilized from 0.22 um filtered solution in PBS with Arginine, pH7.4, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 36.0 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||290|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>90% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
|SDS-PAGE of FGL1-130H :||
Human FGL1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
|Bioactivity-BLI of FGL1-130H :||
Loaded Human LAG-3, Fc Tag on Protein A Biosensor, can bind Human FGL1, His Tag with an affinity constant of 10.1 nM as determined in BLI assay (ForteBio Octet Red96e).
|Gene Name :||FGL1|
|Official Symbol :||FGL1|
|Synonyms :||HPS; HFREP1; HP-041; LFIRE1; LFIRE-1; Hepassocin|
|Gene ID :||2267|
|mRNA Refseq :||NM_004467.4|
|Protein Refseq :||NP_004458.3|
|UniProt ID :||Q08830|
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