Recombinant Human FHIT, His-tagged

• Cat.No.: FHIT-12887H
• Product Overview: Recombinant Human FHIT protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-147a.a.
• Description: This gene, a member of the histidine triad gene family, encodes a diadenosine 5,5-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: His
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: FHIT fragile histidine triad [ Homo sapiens ]
• Official Symbol: FHIT
• Synonyms: FHIT; fragile histidine triad; fragile histidine triad gene; bis(5-adenosyl)-triphosphatase; AP3Aase; FRA3B; AP3A hydrolase; tumor suppressor protein; dinucleosidetriphosphatase; diadenosine 5,5-P1,P3-triphosphate hydrolase
• Gene ID: 2272
• mRNA Refseq: NM_001166243
• Protein Refseq: NP_001159715
• MIM: 601153
• UniProt ID: P49789
• Chromosome Location: 3p14.2
• Pathway: Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Small cell lung cancer, organism-specific biosystem; Small cell lung cancer, conserved biosystem
• Function: bis(5-adenosyl)-triphosphatase activity; catalytic activity; hydrolase activity; nickel cation binding; protein binding