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Recombinant Human Fibroblast Growth Factor 7, His-tagged

Cat.No. : FGF7-682H
Product Overview : Recombinant human FGF7contains 164 amino acids and a 16 aa His-tag. Total length is 180 aa.
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Cat. No. : FGF7-682H
Description : The protein encoded bythis gene is a member of the fibroblast growth factor (FGF) family. FGFfamily members possess broad mitogenic and cell survival activities, and areinvolved in a variety of biological processes, including embryonicdevelopment, cell growth, morphogenesis, tissue repair, tumor growth andinvasion. This protein is a potent epithelial cell-specific growth factor,whose mitogenic activity is predominantly exhibited in keratinocytes but notin fibroblasts and endothelial cells.
Source : Hordeum vulgare(barley grain)
Species : Human
Form : Lyophilized from a0.2 µm sterile filtered solution of PBS, pH 7.2.
Molecular Weight : Predicted MW 21.2kDa including his-tag. The glycosylated recombinant protein migrates with anapparent MW 30 kDa in SDS-PAGE.
Purity : > 98% by SDS-PAGE.Purified product carries no pyrogenic or pro-inflammatory contaminants, asassayed with monocyte activation test using custom human Multiplex CytokineAssay measuring IL-6, TNF-alpha and IL-1beta induction.
Endotoxin Level : < 0.005 ng perµg of product (0.05 EU/µg) as measured by turbidimetric kinetic assay.
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human FGF7 on proliferationof mouse BaF3. The ED50 for a typical batch of recombinant human FGF7is 0.20 ng/ml.
Specific Activity : 5.0 x 106U/mg
Cross-Reactivity : Considerablespecies cross-reactivity, including with mouse, monkey, and pig cells.
Reconstitution : Centrifuge vialprior to opening. First addsterile distilled water to the vial to fully solubilize the protein to aconcentration not less than 100 µg/ml. After complete solubilization of theprotein, it can be further diluted to other aqueous solutions.
Storage : The lyophilizedprotein, though stable at room temperature for two weeks, is best stored at-20°C. Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : FGF7
Gene Name : FGF7 fibroblast growth factor 7[ Homo sapiens ]
Synonyms : FGF7; fibroblastgrowth factor 7; KGF; HBGF-7;keratinocyte growth factor; FGF-7; OTTHUMP00000162252; heparin-binding growthfactor 7
Gene ID : 2252
mRNA Refseq : NM_002009
Protein Refseq : NP_002000
MIM : 148180
UniProt ID : P21781
Chromosome Location : 15q15-q21.1
Pathway : Downstream signalingof activated FGFR; FGFR ligand binding and activation; FGFR2 ligand bindingand activation; FGFR2b ligand binding and activation; FRS2-mediated cascade; Glypican3 network; IRS-mediated signalling; IRS-related events; Insulin receptorsignalling cascade; MAPK signaling pathway; Melanoma; Negative regulation ofFGFR signaling; PI-3K cascade; Pathways in cancer; Phospholipase C-mediatedcascade; SHC-mediated cascade
Function : chemoattractant activity;growth factor activity; heparin binding; type 2 fibroblast growth factorreceptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does FGF7 aid in tissue repair? 11/12/2022

FGF7 stimulates the proliferation and migration of epithelial cells, which are crucial for repairing damaged tissues.

Are there any side effects associated with FGF7 treatment? 05/09/2019

Side effects are generally mild, such as local irritation at the site of application, but comprehensive studies are ongoing.

Can FGF7 be used in regenerative medicine? 06/16/2018

Yes, FGF7 is being explored for its potential in regenerating tissues and promoting healing in various medical fields.

How is FGF7 administered in clinical settings? 08/01/2017

FGF7 can be administered topically or via injection, depending on the specific condition being treated.

Is FGF7 used in dermatology? 02/13/2016

Yes, FGF7 has been investigated for its potential in treating skin disorders, including conditions like psoriasis and atopic dermatitis.

Customer Reviews (3)

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Reviews
03/21/2022

    I highly recommend the FGF7 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.

    05/01/2021

      The FGF7 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.

      10/01/2017

        What truly distinguishes the FGF7 Protein is the unparalleled technical support provided by the manufacturer.

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