Recombinant Human FLG protein, His-tagged

Cat.No. : FLG-1229H
Product Overview : Recombinant Human FLG(Ser3905~Tyr4031) fused with His tag at N-terminal was expressed in E. coli.
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Description : The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300
Molecular Mass : 25kDa
Protein length : Ser3905~Tyr4031
AA Sequence : SHRDTA SHVRSSPVQS DSSTAKEHGH FSSLSQDSAY HSGIQSRGSP
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
SDS-PAGE:
Gene Name : FLG filaggrin [ Homo sapiens ]
Official Symbol : FLG
Synonyms : FLG; filaggrin; epidermal filaggrin; ATOD2;
Gene ID : 2312
mRNA Refseq : NM_002016
Protein Refseq : NP_002007
MIM : 135940
UniProt ID : P20930
Chromosome Location : 1q21.3
Function : calcium ion binding; nucleoside-triphosphatase activity; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a drug that targets the FLG protein? 05/29/2022

There are currently no drugs that directly target FLG protein, but there are some drugs that can affect the expression level and activity of FLG protein, such as some growth factors and cytokines.

How is atopic dermatitis caused by FLG gene mutations treated? 12/19/2021

For atopic dermatitis caused by FLG gene mutations, treatments for inflammation and itching, such as topical glucocorticoids, antihistamines, etc., can also be used for systemic treatments, such as immunosuppressants and biologics.

How do mutations in the FLG protein cause skin diseases? 10/06/2021

Mutations in the FLG protein can cause abnormal keratin fiber structure in keratinocytes, affecting the maturation and differentiation of the stratum corneum, resulting in symptoms such as dryness, scaling, and itching.

Can genetic diagnostics be Used to identify FLG mutations in patients with atopic dermatitis? 03/26/2021

Gene sequencing technology can be used to detect FLG gene mutations in patients with atopic dermatitis, so as to provide a basis for diagnosis and treatment.

How is FLG protein related to atopic dermatitis? 02/24/2020

Patients with atopic dermatitis often have mutations in the FLG gene, which lead to impaired skin barrier function, which in turn causes symptoms such as skin inflammation and itching.

Can skin diseases caused by mutations in the FLG protein be treated? 12/02/2019

Treatment of skin diseases caused by FLG protein mutations includes topical moisturizers, keratin softeners, and anti-inflammatory drugs, as well as systemic treatments such as oral medications, biologics, etc.

Customer Reviews (3)

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Reviews
10/20/2022

    Catalytic activity is excellent, and the catalytic performance is stable regardless of the environment

    07/03/2021

      Will not interact with other reagents, will not affect.

      01/14/2021

        The quality is very good, and their service life is very long, I am very satisfied with this product.

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