Recombinant Human FLG2 Protein (Glu1222-Gln1368), N-His tagged

• Cat.No.: FLG2-2633H
• Product Overview: Recombinant human FLG2 (Glu1222-Gln1368) protein fused with the N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Glu1222-Gln1368
• Description: The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa and E. coli.
• Molecular Mass: 18.47 kDa
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: FLG2 filaggrin family member 2 [ Homo sapiens (human) ]
• Official Symbol: FLG2
• Synonyms: IFPS
• Gene ID: 388698
• mRNA Refseq: NM_001014342
• Protein Refseq: NP_001014364
• MIM: 616284
• UniProt ID: Q5D862