Recombinant Human FLI1, GST-tagged

• Cat.No.: FLI1-12924H
• Product Overview: Recombinant Human FLI1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 170-262a.a.
• Description: This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: FLI1 Friend leukemia virus integration 1 [ Homo sapiens ]
• Official Symbol: FLI1
• Synonyms: FLI1; Friend leukemia virus integration 1; Friend leukemia integration 1 transcription factor; EWSR2; SIC 1; proto-oncogene Fli-1; transcription factor ERGB; SIC-1
• Gene ID: 2313
• mRNA Refseq: NM_001167681
• Protein Refseq: NP_001161153
• MIM: 193067
• UniProt ID: Q01543
• Chromosome Location: 11q24.1-q24.3
• Pathway: Transcriptional misregulation in cancer, organism-specific biosystem; Transcriptional misregulation in cancer, conserved biosystem
• Function: DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity