Recombinant Human FLNA protein, MYC/DDK-tagged FLNA-185H

Recombinant Human FLNA protein, MYC/DDK-tagged

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Recombinant Human FLNA protein, MYC/DDK-tagged

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Cat.No. : FLNA-185H
Product Overview : Recombinant Human FLNA, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
Description : The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 280.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : FLNA filamin A, alpha [ Homo sapiens ]
Official Symbol : FLNA
Synonyms : FLNA; filamin A, alpha; filamin A, alpha (actin binding protein 280) , FLN, FLN1, OPD1, OPD2; filamin-A; ABP 280; actin binding protein 280; filamin-1; alpha-filamin; non-muscle filamin; endothelial actin-binding protein; FLN; FMD; MNS; OPD; ABPX; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280; FLJ43642; DKFZp434P031;
Gene ID : 2316
mRNA Refseq : NM_001110556
Protein Refseq : NP_001104026
MIM : 300017
UniProt ID : P21333
Chromosome Location : Xq28
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-extracellular matrix interactions, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem;
Function : Fc-gamma receptor I complex binding; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; actin binding; actin filament binding; glycoprotein binding; protein binding; protein homodimerization activity; protein kinase C binding; signal transducer activity; small GTPase binding; transcription factor binding;

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