Recombinant Human FLT1 protein, His-Avi-tagged, Biotinylated
Cat.No. : | FLT1-3810H |
Product Overview : | Biotinylated Recombinant Human FLT1 protein(P17948-1)(Ser27-Asn756), fused with C-terminal His and Avi tag, was expressed in HEK293. |
Availability | February 15, 2025 |
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Source : | HEK293 |
Species : | Human |
Tag : | C-His-Avi |
Protein length : | Ser27-Asn756 |
Conjugation/Label : | Biotin |
Form : | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. |
Bio-activity : | Immobilized Human VEGF165 at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human VEGFR1, His Tag with the EC50 of 46.4ng/ml determined by ELISA. |
Molecular Mass : | The protein has a predicted MW of 85.1 kDa. Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result. |
Endotoxin : | Less than 1EU per μg by the LAL method. |
Purity : | > 95% as determined by Tris-Bis PAGE |
Storage : | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
Reconstitution : | Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Gene Name : | FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) [ Homo sapiens ] |
Official Symbol : | FLT1 |
Synonyms : | FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; vascular endothelial growth factor receptor 1; VEGFR1; FLT-1; VEGFR-1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; |
Gene ID : | 2321 |
mRNA Refseq : | NM_001159920 |
Protein Refseq : | NP_001153392 |
MIM : | 165070 |
UniProt ID : | P17948 |
Products Types
◆ Recombinant Protein | ||
FLT1-133H | Active Recombinant Human FLT1 Protein (27-328aa), C-hIgG tagged | +Inquiry |
FLT1-474H | Recombinant Human FLT1 Protein, His-tagged | +Inquiry |
FLT1-2341H | Recombinant Human FLT1 Protein, MYC/DDK-tagged | +Inquiry |
FLT1-923H | Recombinant Human FLT1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Flt1-1785M | Active Recombinant Mouse Flt1 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
FLT1-1909HCL | Recombinant Human FLT1 cell lysate | +Inquiry |
FLT1-1207RCL | Recombinant Rat FLT1 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewthe FLT1 protein is an excellent choice for researchers due to its high quality, reliability, and the comprehensive technical support provided by the manufacturer.
The manufacturer of FLT1 protein provides excellent technical support, ensuring that researchers receive prompt assistance and guidance when encountering any challenges or difficulties.
Researchers can confidently incorporate FLT1 protein into their experiments, knowing that they have access to a reliable resource that will meet their experimental needs effectively.
Q&As (5)
Ask a questionElevated levels of soluble FLT1 have been associated with preeclampsia, a pregnancy complication. Soluble FLT1 acts as a decoy receptor, reducing the bioavailability of VEGF and contributing to vascular dysfunction.
FLT1 has been implicated in retinal diseases like diabetic retinopathy, where abnormal blood vessel growth can lead to vision impairment. Inhibiting FLT1 may help regulate angiogenesis in such conditions.
FLT1 expression is regulated by various factors, including VEGF itself, as well as hypoxia and inflammation. These factors influence the balance of angiogenic signaling.
Yes, elevated levels of soluble FLT1 have been investigated as potential biomarkers for conditions like preeclampsia, cancer, and certain cardiovascular diseases.
Yes, targeting FLT1 is a strategy for anti-angiogenic therapy. Inhibiting FLT1 can impede blood vessel formation, limiting the blood supply to tumors and potentially slowing their growth.
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