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Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Cat.No. : FLT1-1221H
Product Overview : Recombinant humansoluble FLT1 is the naturally occurring form and was cloned from total RNA ofhuman umbilical vein endothelial cells.
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  • Gene Information
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Cat. No. : FLT1-1221H
Description : The recombinant mature soluble FLT1 is aglycosylated monomeric protein consisting of the first 6 extracellulardomains (Met1-His688) containing the unique 31 amino acid residues at theC-terminus.
Source : Insect cells
Species : Human
Form : Lyophilizedwithout additives.
Molecular Weight : 96 kDa
Purity : > 90% asdetermined by SDS-PAGE and visualized by silver stain
Endotoxin Level : < 0.1 ng/µg of FLT1
Biological Activity : Determined by itsability to abolish the binding of iodinated FLT1 to solid surfaces or cellsurface receptors. The ED50 for this effect is typically 10 ng/ml. The usablerange is 5-50 ng/ml.
Reconstitution : Centrifugevial prior to opening. Soluble in water and most aqueous buffers. Add PBS tothe vial to fully solubilize the protein to a concentration not lower than100 ng/ml.
Storage : Lyophilized proteinis stable for 6 months at -20°C to -80°C. Store reconstituted protein inworking aliquots at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name : FLT1 fms-related tyrosine kinase 1(vascular endothelial growth factor/vascular permeability factor receptor) [ Homosapiens ]
Official Symbol : FLT1
Synonyms : FLT1; fms-related tyrosinekinase 1 (vascular endothelial growth factor/vascular permeability factorreceptor); FLT; VEGFR1; FRT; vascular endothelial growth factor receptor 1;EC; VEGFR-1; Vascular permeability factor receptor; Flt-1;Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-liketyrosine kinase 1
Gene ID : 2321
mRNA Refseq : NM_001159920
Protein Refseq : NP_001153392
MIM : 165070
UniProt ID : P17948
Chromosome Location : 13q12
Pathway : Cytokine-cytokinereceptor interaction; Endocytosis; Focal Adhesion; Glypican 1 network;HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilininteractions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; SignalTransduction; Signaling by VEGF; Signaling events mediated by VEGFR1 andVEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGFligand-receptor interactions; VEGFR1 specific signals
Function : ATP binding; growth factorbinding; identical protein binding; nucleotide binding; receptor activity;transferase activity; vascular endothelial growth factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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