Recombinant Human FOXN1 Protein, GST-tagged

• Cat.No.: FOXN1-4467H
• Product Overview: Human FOXN1 full-length ORF ( AAI46540.1, 1 a.a. - 648 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5 UTR of this gene has been observed. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 98.23 kDa
• AA Sequence: MVSLPPPQSDVTLPGPTRLEGERQG DLMQAPGLPGSPAPQSKHAGFSCSS FVSDGPPERTPSLPPHSPRIASPGP EQVQGHCPAGPGPGPFRLSPSDKYP GFGFEEAAASSPGRFLKGSHAPFHP YKRPFHEDVFPEAETTLALKGHSFK TPGPLEAFEEIPVDVAEAEAFLPGF SAEAWCNGLPYPSQEHGPQVLGSEV KVKPPVLESGAGMFCYQPPLQHMYC SSQPPFHQYSPGGGSYPIPYLGSSH YQYQRMAPQASTDGHQPLFPKPIYS YSILIFMALKNSKTGSLPVSEIYNF MTEHFPYFKTAPDGWKNSVRHNLSL NKCFEKVENKSGSSSRKGCLWALNP AKIDKMQEELQKWKRKDPIAVRKSM AKPEELDSLIGDKREKLGSPLLGCP PPGLSGSGPIRPLAPPAGLSPPLHS LHPAPGPIPGKNPLQDLLMGHTPSC YGQTYLHLSPGLAPPGPPQPLFPQP DGHLELRAQPGTPQDSPLPAHTPPS HSAKLLAEPSPARTMHDTLLPDGDL GTDLDAINPSLTDFDFQGNLWEQLK DDSLALDPLVLVTSSPTSSSMPPPQ PPPHCFPPGPCLTETGSGAGDLAAP GSGGSGALGDLHLTTLYSAFMELEP TPPTAPAGPSVYLSPSSKPVALA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FOXN1 forkhead box N1 [ Homo sapiens ]
• Official Symbol: FOXN1
• Synonyms: FOXN1; forkhead box N1; RONU, Rowett nude, WHN, winged helix nude; forkhead box protein N1; FKHL20; Rowett nude; winged helix nude; winged-helix nude; winged-helix transcription factor nude; WHN; RONU
• Gene ID: 8456
• mRNA Refseq: NM_003593
• Protein Refseq: NP_003584
• MIM: 600838
• UniProt ID: O15353