|Product Overview :||Recombinant human full-length GAB1 with a T7-His-TEV cleavage site Tag (31aa) fusion at N-terminal was expressed in E. coli.|
|Source :||E. coli|
|AA Sequence :||MASMTGGQQMGRGHHHHHHENLYFQGGEFSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRP|
|Purity :||> 90% by SDS-PAGE|
|Applications :||1. May be used for in vitro Gab1 mediated cell signaling pathway regulation study for various cells in FGFR1 and IL6 pathway by intracellular delivery of this protein with protein-delivery reagent such as ProFectin Reagent Kit.
2. May be used for protein-protein interaction measurement in vitro for mapping GAB1 binder.
3. As substrate protein for kinase enzymatic assay.
4. Potential biomarker protein, which may be used for diagnostic application of various cancer or asthma.
5. As immunogen for specific antibody production.
|Storage :||Keep at -80 centigrade for long term storage. Product is stable at 4 centigrade for at least 30 days.|
|Concentration :||0.5 mg/mL|
|Storage Buffer :||Sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, Sucrose and DTT.|
|Gene Name :||GAB1|
|Official Symbol :||GAB1 GRB2 associated binding protein 1 [ Homo sapiens (human) ]|
|Synonyms :||GAB1; GRB2 associated binding protein 1; GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1|
|Gene ID :||2549|
|mRNA Refseq :||NM_002039|
|Protein Refseq :||NP_002030|
|UniProt ID :||Q13480|