Recombinant Human GDF9 Protein (Gly320-Arg454), His tagged

• Cat.No.: GDF9-3341H
• Product Overview: Recombinant human GDF9 (Gly320-Arg454) protein fused with His tag was expressed in E. coli.

Specification

• Description: Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: 16.99 kDa
• Protein length: Gly320-Arg454
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: GDF9 growth differentiation factor 9 [ Homo sapiens (human) ]
• Official Symbol: GDF9
• Synonyms: GDF9; growth differentiation factor 9; growth/differentiation factor 9; GDF-9
• Gene ID: 2661
• mRNA Refseq: NM_005260
• Protein Refseq: NP_005251
• MIM: 601918
• UniProt ID: O60383

Reviews

11/14/2021

Expertise in peptide synthesis, accelerates our peptide-related projects.

08/24/2020

Swift protein quantification, improves data reliability in our experiments.

01/31/2019

Outstanding protein-protein interaction studies, boost our research efforts.

Q&As

How does GDF9 influence the proliferation and differentiation of granulosa cells in the ovary?

GDF9 stimulates granulosa cell proliferation and differentiation, essential for healthy ovarian function.

What are the mechanisms by which GDF9 modulates intra-ovarian signaling pathways?

GDF9 interacts with intra-ovarian signaling pathways, coordinating follicle development and ovulation.

How do alterations in GDF9 expression or function affect embryonic development and early pregnancy?

Changes in GDF9 expression impact embryonic development and the success of early pregnancy stages.

What role does GDF9 play in fertility and reproductive outcomes in females?

GDF9 significantly impacts female fertility, affecting egg quality and reproductive potential.

What is the impact of GDF9 mutations on the pathogenesis of ovarian dysfunctions and disorders?

Mutations in GDF9 can lead to ovarian disorders, impacting follicle development and female fertility.

How does GDF9 regulate ovarian follicle development and oocyte maturation?

GDF9 is crucial for ovarian follicle growth and oocyte maturation, influencing female fertility.

How does GDF9 contribute to the regulation of steroidogenesis in ovarian cells?

GDF9 regulates steroid hormone production in ovarian cells, influencing reproductive hormone balance.