Recombinant Human GHR Protein, GST-tagged
Cat.No. : | GHR-4887H |
Product Overview : | Human GHR partial ORF ( NP_000154, 19 a.a. - 118 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. The precise location of this cleavage site has not been determined for the human protein |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | FSGSEATAAILSRAPWSLQSVNPGL KTNSSKEPKFTKCRSPERETFSCHW TDEVHHGTKNLGPIQLFYTRRNTQE WTQEWKECPDYVSAGENSCYFNSSF |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | GHR growth hormone receptor [ Homo sapiens ] |
Official Symbol : | GHR |
Synonyms : | GHR; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; GHBP; |
Gene ID : | 2690 |
mRNA Refseq : | NM_000163 |
Protein Refseq : | NP_000154 |
MIM : | 600946 |
UniProt ID : | P10912 |
Products Types
◆ Recombinant Protein | ||
Ghr-3269M | Active Recombinant Mouse Ghr protein(Met1-Gln273), His-tagged | +Inquiry |
GHR-1623H | Active Recombinant Human GHR Protein, Fc-tagged | +Inquiry |
GHR-279H | Recombinant Human GHR Protein, His-tagged | +Inquiry |
Ghr-6382R | Recombinant Rat Ghr Protein, His (Fc)-Avi-tagged | +Inquiry |
GHR-1279R | Acitve Recombinant Rat GHR protein(Met1-Arg265), hFc-tagged | +Inquiry |
◆ Lysates | ||
GHR-2401MCL | Recombinant Mouse GHR cell lysate | +Inquiry |
GHR-1140RCL | Recombinant Rat GHR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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