Recombinant Human GMNN Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human GMNN Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : GMNN-3132H
Product Overview : GMNN MS Standard C13 and N15-labeled recombinant protein (NP_056979) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 23.6 kDa
AA Sequence : MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCIT RTRPLEQKLI SEEDLAANDI LDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : GMNN geminin DNA replication inhibitor [ Homo sapiens (human) ]
Official Symbol : GMNN
Synonyms : GMNN; geminin, DNA replication inhibitor; geminin; Gem;
Gene ID : 51053
mRNA Refseq : NM_015895
Protein Refseq : NP_056979
MIM : 602842
UniProt ID : O75496

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