Recombinant Human GNB5, His-tagged

• Cat.No.: GNB5-29091TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-353 of Human GNB5 isoform 2, with a N terminal His tag; MWt 46kDa

Specification

• Description: Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed in multiple tissues.
• Form: Lyophilised:Reconstitution with 112 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQ VAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRI VSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPS GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYL SACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGH GADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCV QAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRA DREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVW DVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHT LRVWA
• Sequence Similarities: Belongs to the WD repeat G protein beta family.Contains 7 WD repeats.

Gene Information

• Gene Name: GNB5 guanine nucleotide binding protein (G protein), beta 5 [ Homo sapiens ]
• Official Symbol: GNB5
• Synonyms: GNB5; guanine nucleotide binding protein (G protein), beta 5; guanine nucleotide-binding protein subunit beta-5; GB5
• Gene ID: 10681
• mRNA Refseq: NM_006578
• Protein Refseq: NP_006569
• MIM: 604447
• Uniprot ID: O14775
• Chromosome Location: 15q21.1
• Pathway: ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem; Aquaporin-mediated transport, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem
• Function: GTPase activity; signal transducer activity